Archives of Maryland
(Biographical Series)
Henrietta Lacks
(1920-1951)
MSA SC 3520-16887
Biography:
Despite living a very short life,
Henrietta Lacks is one of
the most important people in the history of medicine. Lacks’ cells,
known as
the HeLa cell line, are mysteriously immortal and have been used by
scientists
and researchers all over the world to study and develop cures for a
plethora of
diseases. For decades, Lacks and her family were not given any
recognition for
her contribution to the medical field, but, in recent years, Henrietta
Lacks’
legacy has been credited for saving the lives of millions.
Henrietta Lacks was born as Loretta Pleasant in Roanoke, Virginia in August 1920 to Johnny and Eliza Pleasant, both African American. No one is aware when she changed her name to Henrietta from Loretta. Lacks’ mother died when she was only five, and
she was then sent to live in Clover, Virginia with her grandfather in a log
cabin that was previously the slave quarters on her white great-grandfather’s plantation.1 While
slavery was still legal, Lacks’ white great-grandfather took a slave
mistress,
thus starting Henrietta’s family line of black Lackses.2
When
she was old enough, Lacks began farming tobacco on the plantation like
the rest
of her family.
Lacks gave birth to her first child soon after her
fourteenth birthday, and the father of the child was her first cousin, David "Day" Lacks.3
Henrietta and Day named their first son Lawrence and, four years
later,
Lacks gave birth to her second child and first daughter, Eliza. On
April 10,
1941, Henrietta, age 20, married Day, age 25. Soon after their
marriage, Day
moved to Baltimore
to take advantage of the large amount of opportunity in the steel
factories
during World War II, and Henrietta and the two children soon followed.
While living in Baltimore,
Henrietta gave birth to three more children. She “spent her time
cooking for
Day, the children, and whichever cousins happened to be at her house.
She made
her famous rice pudding and slow-cooked greens, chitlins, and the vats
of
spaghetti with meatballs she kept going on the stove for whenever
cousins
dropped by hungry.”4
One of
her friends reflected that “Hennie made life come alive—bein with her
was like
bein with fun. Hennie just love peoples. She was a person that could
really
make the good things come out of you.”5
Although
Henrietta Lacks held the ability to make the good come out of people,
something
lethal was growing inside her body. She began telling her family and
friends
that she had a knot in her womb or that she was bleeding even though it
was not
her time of the month.6
After
feeling something strange on her cervix, Lacks knew it was imperative
for her
to go visit a doctor.
Lacks made an appointment at The Johns
Hopkins Hospital
in Baltimore
and her biopsy results determined that she had Stage I epidermoid
carcinoma of
the cervix, or cervical cancer. The doctor that examined her found it
incredibly interesting that even though she had no cervical abnormalities when she
delivered a baby at Hopkins
three months prior, she now returned to the hospital
with a
cancerous tumor.7
After
the mass was diagnosed as cancerous, Lacks was instructed to return to
the
hospital to begin radium treatment. Radium was known to cause cancer,
but it
was also known to kill cancer. Unfortunately, it was also known to burn
the
skin, which is exactly what happened to Lacks during her treatment.
Those close
to her were horrified when Lacks confided in them the damage from her
treatment,
telling them that “Lord it just feels like that blackness be spreadin
all
inside me.”8
That “blackness,” her cancer, was actually spreading all
inside her. In August 1951, Lacks returned to Hopkins, asking
to be admitted because her
pain was unbearable. She died a grim death on October 4, 1951 at age 31
from
cancer that had metastasized throughout her entire body. Lacks was
buried in a
wooden box in an unmarked grave in Clover, Virginia. What
Henrietta Lacks and her
family did not know, however, was that she would live on forever
through her
cells. During her cancer treatment at Johns Hopkins, her doctor took
healthy
and cancerous samples from Lacks’ cervix without informing her of his
actions
or getting consent from her, and gave them to George Gey, a cancer
researcher. This
was standard practice, and, at the time
of Lacks’s death, there were no state or federal laws regarding
obtaining
consent from any patient.9
Gey was constantly analyzing human cells in an effort to create the
perfect
culture medium, or the liquid used for feeding cells. After being
placed in a
Petri dish, the cells would usually die within a few hours, but Gey
found that
Henrietta’s cells did something amazing. Her cells kept reproducing.
Gey started his own cell line, which he named HeLa in
tribute to Henrietta Lacks. Neither Gey nor his assistant revealed the
name of
the original owner of the immortal cell line, thus making Lacks’ name
unknown
to the public. The medical breakthroughs from the usage of HeLa cells
quickly
began after Lacks’ death. A scientist named Jonas Salk proclaimed that
he had
found a cure to polio but needed to test the vaccine first. Salk
acquired some
HeLa cells, and, in 1954, Salk released the vaccine that prevented
polio. Millions
of lives were saved from this disease, thanks to the testing performed
on the
HeLa cells.
Since Gey did not patent his HeLa cells, labs all over the
world soon began obtaining these unique cells for research and
experiments.
HeLa cells even went to space when the United States
wanted to test how
human cells would react in zero gravity, and were used to determine the
affects
of the atomic bomb.10
Scientists
used HeLa cells to study molecular biology, virology, and genetics.
Lacks’
cells were also used for research on cancer, AIDS, and, more recently,
Human
Papillomavirus (HPV) and In Vitro Fertilization (IVF). Vaccines and
drugs for
diseases such as herpes, leukemia, influenza, hemophilia, and
Parkinson’s
disease were also developed through testing done on HeLa cells.
Henrietta Lacks’ cells were being used to make scientific breakthroughs beyond many researchers’ wildest dreams, but her family
was
unaware of Henrietta’s contribution to science. In 1953, a reporter at
the Minneapolis Star claimed that
the HeLa
cells belonged to a woman named Henrietta Lakes,
alerting people
for the first time that these were human cells.11
Other
reporters claimed that HeLa stood for Helen Lane
or Helen Larson.12
Either way, the name Henrietta Lacks was never published, and the Lacks
family
was unaware that Henrietta’s cells were being circulated around the
globe until
1973.
One day in 1973, Bobbette Lacks, Lawrence’s
wife, was having lunch with her friend and her friend’s brother-in-law.
The
brother-in-law and Bobbette discovered that they were from the same
part of Baltimore,
and Bobbette
told him that her last name was Lacks. Her friend’s brother-in-law told
Bobbette that he worked at the National Cancer Institute and that he
had been
working for years with cells in his lab that he just recently learned
belonged
to a woman named Henrietta Lacks. Bobbette soon learned that this man,
like
many others around the world, had her mother-in-law’s cells in their
labs.13
Thus
began the anger, confusion, and frustration that would consume the
Lacks family
for decades.
The Lacks family, still living in Baltimore City,
was impoverished and in poor health. They were being harassed by
doctors and
researchers for blood samples and developed a serious mistrust of Johns
Hopkins Hospital.
They felt that
they had been robbed by Hopkins
and thought that Henrietta was still alive and her body was being held
hostage
in the hospital. Some members of the family thought that suing the
hospital for
taking a part of Henrietta without her consent or knowledge was the
proper
path, but they would soon learn their case was fruitless. Around the
same time
the Lacks family discovered the truth about the HeLa cells, a
Californian man
named Roger Moore was attempting to sue his doctor for unknowingly
scraping his
cells and profiting from them. The case finally reached the Supreme
Court of
California, and the court ruled that “When tissues are removed from
your body,
with or without your consent, any claim you might have had to owning
them
vanishes. When you leave tissues in a doctor’s office or a lab, you
abandon
them as waste, and anyone can take your garbage and sell it.”14
This
ruling set a precedent, stripping a large amount of power away from
patients
and legally allowing doctors and researchers to financially exploit
their
patients if they discovered something medically groundbreaking. This
opened a
global debate about bioethics, but also left the Lacks’ family without
a legal
case.
In 1997, the British Broadcasting Corporation (BBC) came to Baltimore
to interview the Lacks family for a documentary about the HeLa cells’
role in
cancer research. This gained some publicity about the woman behind the
HeLa
cells, and, in the same year, then United States Representative Robert L. Ehrlich,
Jr.
formally addressed Congress about Lacks, saying that “Henrietta Lacks’
selfless
contribution to the field of medicine has gone without acknowledgement
for far
too long. Her cells made her immortal: through her death, countless
others have
been saved by the research that was made possible through her cell
line…I
sincerely hope her name will also be immortalized as one of courage,
hope, and
strength, and that due recognition will be given to her role in
medicine and
science.”15
Henrietta’s
enormous contribution to decades of science was recognized, but true
justice
for Henrietta still seemed hopeless.
Hope came to the Lacks family a few years later in the form
of a young, white, female writer named Rebecca Skloot. Skloot became
fascinated with
the mystery behind the HeLa cells at age sixteen and spent many years
trying to
uncover the story behind the immortal cells. The Lacks,
understandably, were mistrusting of Skloot and her motives. Skloot, however, proved to
be
faithful to the family in regards to spreading their story, and she
became the
closest with Henrietta’s daughter, Deborah. Deborah never knew her
mother but
always wanted to understand what happened to her. Through Deborah,
Skloot was
able to better understand the struggles of the family and tell the
story of
Henrietta, and through Skloot, Deborah was able to learn about her
mother and
even hold her cells. Skloot published The
Immortal Life of Henrietta Lacks in 2010 and describes the
book as “not
only the story of HeLa cells and Henrietta Lacks, but of Henrietta’s
family—particularly Deborah—and their lifelong struggle to make peace
with the
existence of those cells, and the science that made them possible.”16
The novel became an instant best-seller and was even comissioned by
Oprah Winfrey to be made
into a movie. The Lacks family was finally given the recognition they
struggled
for years to gain.
In 2013, 62 years after Henrietta’s death, the Lackses were
finally able to have a voice in the distribution of HeLa cells.
Controversy
began again in early 2013 after a German lab published the HeLa genome
in an
online magazine. The German research lab published the paper “to show
the
degree to which the genomes of HeLa cells diverged from those of
healthy cells,
so researchers could take that into account when designing experiments
and
analyzing results from studies using the HeLa cell line,” but the Lacks
family
worried that others would be able to formulate their genetic codes
through this
public information.17
The article was taken down, but the Lackses still felt their biological
information was being distributed without their consent and that
“history was
repeating itself” since anyone could get a hold of Henrietta’s genomes.18
In
August 2013, an agreement between the Lackses and the National
Institute of
Health (NIH) was formulated, decreeing that scientists had to obtain
permission
from the NIH in order to conduct research on HeLa cells. The NIH and
two
members of the Lacks family would approve or reject the applications as
they
saw fit. Finally, the Lacks family could stop the outright exploitation
of Henrietta.
Henrietta Lacks did not live a long life, but her cells will
live on forever. She has had a greater impact on science than any other
scientist or researcher will ever claim, and her cells have been used
to save
the lives of a countless number of people and animals. As the most
important
person in medicine, and as a former Maryland resident, Henrietta Lacks
will be
immortalized as an important Maryland woman through her induction into
the 2014
Women’s Hall of Fame.
1. Henrietta
Lacks Women's Hall of Fame 2014 Nomination Packet.
Return to text2.
“The Way
of All Flesh,” Adam Curtis, available on YouTube: https://www.youtube.com/watch?v=C0lMrp_ySg8. Return to text
3.
Rebecca Skloot, The Immortal Life of Henrietta Lacks, (New York: Crown Publishers, 2010), 23. Return to text
9. Alok Jha and Rebecca Skloot, "The 'immortal' Henrietta Lacks--Science Weekly,"
podcast audio, The Guardian: Science Weekly, accessed June 25, 2014,
http://www.theguardian.com/science/blog/audio/2010/jun/21/science-weekly-podcast-henrietta-lacks-rebecca-skloot?commentpage=1.
Return to text
15.
Robert L. Ehrlich, Jr., "In Memory of Henrietta Lacks" (June 4, 1997),
Congressional Record Volume 143, Number 75,
https://beta.congress.gov/congressional-record/1997/06/04/extensions-of-remarks-section/article/E1109-1.
Return to text
17.
“German
lab apologizes for publishing the genome of ‘immortal’ woman’s cell
line,” Washington Post, April 2,
2013. Return to text
18.
Andrea
K. Walker, “Lacks’ kin finally get say in use of her cells: After
decades, NIH
accord requires permission to use her genome in research,” Baltimore Sun, August 8, 2013. Return to text
Biography written by 2014 summer intern Sharon Miyagawa.
Return
to Henrietta Lacks' Introductory Page
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