113W10
Print Request:   Current Document: 6

Time of Request: July 13, 2001  11:44 am EST

Number of Lines: 45
Job Number:      59:0:31152396

Client ID/Project Name: other
 
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Send to:  ALVEY, CHRISTINE
          MARYLAND STATE ARCHIVES-HALL OF RECORDS
          350 ROWE BLVD
          ANNAPOLIS, MARYLAND 21401-1685

           

6 of 9 DOCUMENTS 

Copyright 1985 The San Diego Union-Tribune 

The San Diego Union-Tribune 

May 17, 1985, Friday 

SECTION: NEWS; Ed. 1,2,3,4,5,6; Pg. A-27 

LENGTH: 387 words 

HEADLINE: Despite failures, U.S. panel says, marrow transplants should go on 

SOURCE:  AP 

BODY: 
Bone marrow transplants between unrelated people have been only marginally successful so far, but doctors should continue to use the technique while seeking ways to improve it, experts say.  recipients appear adequate, it said. 
Convened by the National Institutes of Health to assess marrow transplant technology and donor registries, the group encouraged attempts to perform the transplants among genetically unrelated people. 
Although survival has been poor, the panel said, "continuing efforts with the use of unrelated donors are certainly warranted." 
The group called for a national clearinghouse to coordinate information among the half-dozen local registries, gather data on marrow transplants in general and provide information to the public and professionals. 
The conference chairwoman, Dr. Brigid Leventhal of the National Cancer Institute, said the proposed coordinating center would be an interim measure that would be evaluated after two years. 
"We feel a coordinated network of local registries would do the job right now," she said. 
The recommendations are being forwarded to the Department of Health and Human Services, which last year was directed by Congress to look into the possibility of setting up a national registry of unrelated donors. 
Marrow, the spongy substance within bones, produces blood components such as red cells which carry oxygen and white cells which defend against infection.  If marrow stops functioning, as with the disease aplastic anemia, or is replaced by abnormal cells, as with cancerous leukemia, a transplant from someone else may help. 
About 1,000 bone marrow transplants are done each year in the United States, most using the marrow of genetically matched siblings.  The closer the match, the less likely a form of rejection called graft-versus-host disease will occur. 
The patient's own defective marrow is destroyed with drugs or radiation, suppressing their immune system, and donor marrow injected.  A month or two later, the donor graft activates and attacks the host tissues as foreign substances. 
The survival rate for bone marrow transplants generally is about 50 percent.  Graft-versus-host disease contributes to the death of up to 40 percent of transplant patients, the review panel said in its draft report.  the panel said.  

LOAD-DATE: August 8, 1996 

                                                                         113W10
**********  Print Completed  **********

Time of Request:   July 13, 2001  11:44 am EST

Print Number:      59:0:31152396
Number of Lines:   45
Number of Pages:   

Send To:  ALVEY, CHRISTINE
          MARYLAND STATE ARCHIVES-HALL OF RECORDS
          350 ROWE BLVD
          ANNAPOLIS, MARYLAND 21401-1685